Developmental origin of pre-DC2
Autor: | Suzanne J. Ligthart, Remko Schotte, Hergen Spits, Bianca Blom |
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Přispěvatelé: | Cell Biology and Histology, Other departments, Tytgat Institute for Liver and Intestinal Research |
Jazyk: | angličtina |
Rok vydání: | 2002 |
Předmět: |
Myeloid
T cell Cellular differentiation Immunology Population CD2 Antigens Antigens CD34 Thymus Gland Biology medicine Animals Humans Immunology and Allergy Cell Lineage Progenitor cell education education.field_of_study Gene Expression Regulation Developmental Cell Differentiation Dendritic Cells General Medicine Fetal Blood Hematopoietic Stem Cells Cell biology Haematopoiesis medicine.anatomical_structure Bone marrow Stem cell |
Zdroj: | Human immunology, 63(12), 1072-1080. Elsevier Inc. |
ISSN: | 0198-8859 |
Popis: | It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is still limited but is increasing rapidly. Here we will summarize recent findings on the developmental origin of the precursor of DC2 (pre-DC2). The presence of pre-DC2 has been revealed in bone marrow, fetal liver, and cord blood, where they develop from hematopoietic stem cells (HSC) most likely via an intermediate pro-DC2 stage. Both in human and mouse, development of pre-DC2 depends on the cytokine FLT3-ligand (FLT3-L). In addition, transcription factors such as Spi-B and members of the basic helix-loop helix (bHLH) family have been shown to be involved in the proper differentiation of HSC into pre-DC2. The human thymus contains a population of cells that closely resembles the peripheral pre-DC2, including interferon (INF)-a production after viral stimulation. Some phenotypic differences have been observed however. Furthermore, we have shown that the thymic microenvironment is able to support development of pre-DC2 from HSC in vivo. A thymus independent pathway of pre-DC2 development exists as well, although at present it is not clear where these extrathymic pre-DC2 are generated. In regard of the absence of a phenotypic defined pro-DC2 population in the thymus, we speculate that development of thymic pre-DC2 may differ from peripheral pre-DC2. The challenge of the near future will be to determine the role of pre-DC2 during thymic T cell development. |
Databáze: | OpenAIRE |
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