Gender Differences in Complete Blood Count and Inflammatory Ratios among Patients with Bipolar Disorder

Autor: Guendalina Zappa, Antimo Natale, Andrea Aguglia, Gianluca Serafini, Eugenio Aguglia, Laura Fusar-Poli, Mario Amore, Patriciu Cimpoesu, Pietro Grimaldi Filioli, Andrea Amerio
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Population
Female group
Article
lcsh:RC321-571
03 medical and health sciences
monocyte-to-lymphocyte
0302 clinical medicine
Internal medicine
mental disorders
gender
Medicine
Bipolar disorder
education
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Depression (differential diagnoses)
bipolar disorder
education.field_of_study
medicine.diagnostic_test
business.industry
General Neuroscience
Complete blood count
biomarkers
medicine.disease
platelet-to-lymphocyte
030227 psychiatry
Peripheral
inflammation
platelets
monocyte
Biomarker (medicine)
eosinophils
medicine.symptom
neutrophil-to-lymphocyte
business
Mania
030217 neurology & neurosurgery
Biomarkers
Eosinophils
Gender
Inflammation
Monocyte
Monocyte-to-lymphocyte
Neutrophil-to-lymphocyte
Platelet-to-lymphocyte
Platelets
Red blood cells
red blood cells
Zdroj: Brain Sciences
Volume 11
Issue 3
Brain Sciences, Vol 11, Iss 363, p 363 (2021)
ISSN: 2076-3425
DOI: 10.3390/brainsci11030363
Popis: Background: Evidence suggested that inflammation may be involved in the etiopathogenesis of bipolar disorder (BD), a chronic psychiatric condition affecting around 2-3% of the general population. However, little is known regarding potential gender differences in peripheral biomarkers of BD, such as neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios. Methods: In total, 197 females and 174 males with BD in different phases (i.e., (hypo)mania, depression, euthymia) were recruited. A blood sample was drawn to perform a complete blood count (CBC). NLR, PLR, and MLR were subsequently calculated, and differences were computed according to the illness phase and gender. Results: PLR was consistently higher in (hypo)manic than depressed patients, in both males and females. No significant gender differences in PLR value were found when considering only (hypo)mania. Conversely, NLR was increased in (hypo)mania only among males, and gender differences were retrieved in the (hypo)manic subgroup. The findings related to MLR were only marginally significant. Higher platelets values were associated with (hypo)mania only in the female group. Basophils and eosinophils appeared gender- but not state-dependent. Conclusions: Our findings provide further evidence that increased PLR levels may be associated with (hypo)mania in bipolar patients, regardless of gender. Moreover, the usefulness of NLR as a peripheral biomarker of BD appeared limited to males while the role of platelets to females. As CBC represents a low-cost and easily accessible test, researchers should investigate in-depth its potential usefulness as a biomarker of BD and other psychiatric disorders.
Databáze: OpenAIRE
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