Spindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA)
| Autor: | Wolfgang Saeger, Armin Riecke, René Mathieu, Chris Schulz, Uwe Max Mauer, Carsten Hackenbroch, Hanno M Witte |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pituitary gland
medicine.medical_specialty Pathology business.industry Sphenoparietal sinus General Medicine Chromophobe cell medicine.disease Sixth nerve palsy Metastasis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Ptosis Pituitary adenoma 030220 oncology & carcinogenesis medicine Surgery Histopathology Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | British Journal of Neurosurgery. :1-6 |
| ISSN: | 1360-046X 0268-8697 |
| DOI: | 10.1080/02688697.2018.1533107 |
| Popis: | We report the case of a 61-year-old male with spindle cell oncocytoma of the hypophysis. On presentation to the Department of Neurosurgery at the German Armed Forces Hospital of Ulm, the patient reported a history of several years of left sixth nerve palsy, right ptosis, increased sensitivity to light, and a bilateral retrobulbar pressure sensation. Pituitary function was normal. A chromophobe non-functioning pituitary adenoma was initially suspected. The diagnosis was established on the basis of examination at a histopathology reference laboratory using immunohistochemistry to identify cell surface markers. During two years of follow-up, there were two clinical recurrences requiring surgery. To our knowledge, this is the 35th documented case of spindle cell oncocytoma of the pituitary gland and the first that was immunohistochemically negative for epithelial membrane antigen (EMA) and S100; and the first that displayed haematogenous metastasis to the right sphenoparietal sinus. The three surgical procedures were associated with massive intraoperative bleeding and thus resulted in subtotal tumor resection. Following surgery for the recurrences, the patient underwent radiotherapy. |
| Databáze: | OpenAIRE |
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