Discrimination of Self and Non-Self Ribonucleic Acids
| Autor: | Beatrice T. Laudenbach, Anna Gebhardt, Andreas Pichlmair |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
RIG-I Immunology Pattern recognition receptor Reviews MDA5 Autoimmunity Cell Biology Biology Acquired immune system 03 medical and health sciences 030104 developmental biology Biochemistry Virology Receptors Pattern Recognition Sense (molecular biology) Nucleic acid biology.protein Animals Humans RNA Viral Receptor Polymerase |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 37(5) |
| ISSN: | 1557-7465 |
| Popis: | Most virus infections are controlled through the innate and adaptive immune system. A surprisingly limited number of so-called pattern recognition receptors (PRRs) have the ability to sense a large variety of virus infections. The reason for the broad activity of PRRs lies in the ability to recognize viral nucleic acids. These nucleic acids lack signatures that are present in cytoplasmic cellular nucleic acids and thereby marking them as pathogen-derived. Accumulating evidence suggests that these signatures, which are predominantly sensed by a class of PRRs called retinoic acid-inducible gene I (RIG-I)-like receptors and other proteins, are not unique to viruses but rather resemble immature forms of cellular ribonucleic acids generated by cellular polymerases. RIG-I-like receptors, and other cellular antiviral proteins, may therefore have mainly evolved to sense nonprocessed nucleic acids typically generated by primitive organisms and pathogens. This capability has not only implications on induction of antiviral immunity but also on the function of cellular proteins to handle self-derived RNA with stimulatory potential. |
| Databáze: | OpenAIRE |
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