Repair of Peripheral Nerve Defects With Epineural Sheath Grafts
| Autor: | Maria Siemionow, Abir Lal Mukherjee, Yavuz Demir |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Sensation Transplantation Autologous Neurosurgical Procedures Peripheral nerve Epineurium Evoked Potentials Somatosensory medicine Animals Peripheral Nerves Muscle Skeletal Alternative methods business.industry Anatomy Fascicle Sciatic Nerve Hindlimb Nerve Regeneration Rats Surgery Muscular Atrophy Plastic surgery surgical procedures operative medicine.anatomical_structure Rats Inbred Lew business |
| Zdroj: | Annals of Plastic Surgery. 65:546-554 |
| ISSN: | 0148-7043 |
| Popis: | In this study, we investigated the potential of using a detubulized flat epineural sheath for bridging nerve gaps as an alternative to nerve autografting. Nerve gaps were created by removing a 1.2-cm segment of sciatic nerves. Later, the epineurium was incised longitudinally, and after fascicle removal, a flat rectangular epineural sheath was created. Five experimental groups (6 rats each) included: autograft and no treatment controls and epineural sheath groups repaired with 1 strip, 2-strip, and full epineural sheath grafts. Assessments performed at 3, 6, and 12 weeks included functional (pinprick, toe-spread), neurosensory (somatosensory-evoked potentials), and histomorphometric evaluations. The functional results of toe-spread, somatosensory-evoked potentials, and histomorphometric data revealed comparable outcomes between autograft, 2-strip, and full sheath grafts, indicating adequate nerve regeneration. Thus, the new epineural sheath graft technique introduced in this study can be considered as an alternative method to standard nerve autografting technique. |
| Databáze: | OpenAIRE |
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