Oral Lichen Planus – Known and Unknown: a Review
| Autor: | Milena N Draganova-Filipova, George T Tomov, Plamen Zagorchev, Maria Z. Mutafchieva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Lichenoid Eruptions diagnosis etiology Population Treatment outcome Mucocutaneous zone lcsh:Medicine Autoimmunity Disease Hepacivirus OLP Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors malignant potential Medicine Humans Genetic Predisposition to Disease education Heat-Shock Proteins education.field_of_study Human papillomavirus 16 treatment business.industry pathogenesis lcsh:R 030206 dentistry General Medicine medicine.disease Dermatology Calcineurin Etiology Oral lichen planus Female business Immunosuppressive Agents Stress Psychological Lichen Planus Oral |
| Zdroj: | Folia Medica, Vol 60, Iss 4, Pp 528-535 (2018) |
| ISSN: | 1314-2143 |
| Popis: | Lichen planus is a chronic mucocutaneous inflammatory disease aff ecting 1-2% of the general population with maximum prevalence of the disease in women above the age of 40. Its aetiology remains unclear and the pathogenesis is still the object of much speculation. It is considered to be an autoimmune disorder mediated mainly by the T-lymphocytes. The present paper presents the most well-known external agents (viruses in particular), internal agents like stress, and the heat shock protein thought to be trigger factors and describes the action of diff erent cells and proteins associated with the development of that disease. Diagnosis is based on clinical and histopathologic evidence; direct and indirect immunofluorescence techniques can also be of use. Despite the wide variety of therapeutic modalities, treatment outcomes are often insufficient. Currently, topical corticosteroids are widely accepted as a standard therapy, but also retinoids, calcineurin inhibitors and other immunosuppressants can be administered. Because of the aspect relevant to these drugs, priority is given to alternative harmless methods such as LLLT and PDLT. There is an ongoing controversy in the literature about the possible premalignant character of oral lichen planus, however, periodic followup is recommended. |
| Databáze: | OpenAIRE |
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