Steroid hormones and CNS sexual dimorphisms modulate symptom expression in tourette's syndrome
| Autor: | David L. Keefe, Lawrence Scahill, Nancy J. Charest, James F. Leckman, Frederick Naftolin, Bradley S. Peterson, Donald J. Cohen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder Adolescent Endocrinology Diabetes and Metabolism Tourette's syndrome medicine.medical_treatment Steroid Endocrinology Degenerative disease Clinical investigation medicine Humans Sexual Maturation Child Gonadal Steroid Hormones Biological Psychiatry Brain Mapping Endocrine and Autonomic Systems Brain medicine.disease Sexual dimorphism Psychiatry and Mental health Gene Expression Regulation Clinical evidence Androgens Female Psychology Neuroscience Tourette Syndrome Hormone |
| Zdroj: | Psychoneuroendocrinology. 17:553-563 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/0306-4530(92)90015-y |
| Popis: | We present our hypothesis that various steroid hormones play an important role in the symptom expression of Gilles de la Tourette's syndrome (TS) and that androgenic hormones, in particular, are likely to exacerbate symptoms of the disorder. We review the clinical evidence supporting our hypothesis. Sex steroids establish brain sexual dimorphisms early in CNS development, and we suggest mechanisms whereby androgenic and other hormonal changes later in human development might act at dimorphic brain regions to influence the natural history of TS. Finally, we discuss the various ways in which neuroendocrine studies might assist in genetic and neurobiologic research programs in TS. |
| Databáze: | OpenAIRE |
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