Genomics spawns novel approaches to mosquito control
| Autor: | Marika F. Walter, Spiros D. Dimitratos, Daniel Woods, Robin W. Justice, Harald Biessmann |
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| Rok vydání: | 2003 |
| Předmět: |
Models
Anatomic Mosquito Control DEET Receptors Cell Surface Biology Receptors Odorant Models Biological General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound SAFER Anopheles medicine Animals Humans Neurons Comparative genomics Genome business.industry fungi medicine.disease biology.organism_classification Genetically modified organism Biotechnology Mosquito control Drug development chemistry Insect Repellents Female business Malaria |
| Zdroj: | BioEssays. 25:1011-1020 |
| ISSN: | 1521-1878 0265-9247 |
| DOI: | 10.1002/bies.10331 |
| Popis: | In spite of advances in medicine and public health, malaria and other mosquito-borne diseases are on the rise worldwide. Although vaccines, genetically modified mosquitoes and safer insecticides are under development, herein we examine a promising new approach to malaria control through better repellents. Current repellents, usually based on DEET, inhibit host finding by impeding insect olfaction, but have significant drawbacks. We discuss how comparative genomics, using data from the Anopheles genome project, allows the rapid identification of members of three protein classes critical to insect olfaction: odorant-binding proteins, G-protein-coupled receptors, and odorant-degrading enzymes. A rational design approach similar to that used by the pharmaceutical industry for drug development can then be applied to the development of products that interfere with mosquito olfaction. Such products have the potential to provide more complete, safer and longer lasting protection than conventional repellents, preventing disease transmission by interrupting the parasite life cycle. BioEssays 25:1011–1020, 2003. © 2003 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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