Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products
| Autor: | Erin Dippold, Seth P. Forster, Tiffany Chiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Pharmaceutical Science 02 engineering and technology Review 021001 nanoscience & nanotechnology equipment and supplies 030226 pharmacology & pharmacy melt granulation RS1-441 03 medical and health sciences Granulation 0302 clinical medicine Pharmacy and materia medica Chemical engineering Rheology Extrusion Physical stability twin-screw granulation Immediate release 0210 nano-technology continuous processing |
| Zdroj: | Pharmaceutics, Vol 13, Iss 665, p 665 (2021) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt granulation since it is a flexible and continuous process. Methods for binder selection are profiled with a focus on rheology and physical stability impacts. For twin-screw melt granulation, the mechanism of granulation and process impact on granule properties are described. Pharmaceutical applications of melt granulation ranging from immediate release of soluble and insoluble APIs, taste-masking, and sustained release formulation are reviewed, demonstrating the range of possibilities afforded by twin-screw melt granulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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