Ultrafast imaging Raman spectroscopy of large-area samples without stepwise scanning
| Autor: | Gisela Thiede, Maxim E. Darvin, Benito Moralejo, Martin Roth, Elmar Schmälzlin, D. Bodenmüller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Medical diagnostic
Materials science 01 natural sciences lcsh:Technology Astronomical observatories 010309 optics symbols.namesake Optics Image recording Skin tissue Spectrographs 0103 physical sciences Diagnosis Porcine skin Electrical and Electronic Engineering Instrumentation Spectrograph Single exposure business.industry lcsh:T Spatially resolved 010401 analytical chemistry Computerized tomography 0104 chemical sciences 621.3 symbols business Raman spectroscopy Ultrashort pulse |
| Zdroj: | Journal of Sensors and Sensor Systems, Vol 5, Iss 2, Pp 261-271 (2016) |
| ISSN: | 2194-8771 2194-878X |
| Popis: | Step-by-step, time-consuming scanning of the sample is still the state-of-the-art in imaging Raman spectroscopy. Even for a few 100 image points the measurement time may add up to minutes or hours. A radical decrease in measurement time can be achieved by applying multiplex spectrographs coupled to imaging fiber bundles that are successfully used in astronomy. For optimal use of the scarce and expensive observation time at astronomical observatories, special high-performance spectrograph systems were developed. They are designed for recording thousands of spatially resolved spectra of a two-dimensional image field within one single exposure. Transferring this technology to imaging Raman spectroscopy allows a considerably faster acquisition of chemical maps. Currently, an imaging field of up to 1 cm2 can be investigated. For porcine skin the required measurement time is less than 1 min. For this reason, this technique is of particular interest for medical diagnostics, e.g., the identification of potentially cancerous abnormalities of skin tissue. |
| Databáze: | OpenAIRE |
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