Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum
| Autor: | Hideo Iio, Mayumi Sugiura, Terue Harumoto, Yoshinosuke Usuki, Yoshiyuki Uruma |
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| Rok vydání: | 2007 |
| Předmět: |
Clinical Biochemistry
Protozoan Proteins Pharmaceutical Science Aminophenols Biochemistry Drug Discovery Hydroxybenzoates Animals Sex Attractants Mating Receptor Molecular Biology Fluorescent Dyes Ciliate biology Chemistry Blepharisma japonicum Organic Chemistry biology.organism_classification Receptors Pheromone Sex pheromone Lactates Molecular Medicine Protozoa Pheromone Molecular probe |
| Zdroj: | Bioorganic & Medicinal Chemistry. 15:1622-1627 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2006.12.021 |
| Popis: | Blepharismone (gamone 2) is a mating-inducing pheromone of the ciliate Blepharisma japonicum. N-Pyrenylbutyryl-blepharismone and N-biphenylacetyl-blepharismone, which are fluorescent derivatives of blepharismone, were synthesized as molecular probes for the gamone 2 receptor. Further, we proved that they have inhibitory activities against the blepharismone-induced monotypic pairing of B. japonicum. |
| Databáze: | OpenAIRE |
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