Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder
| Autor: | Maurício Anés, Ana Claudia Mércio Loredo Souza, Flávio Kapczinski, Bianca Wollenhaupt de Aguiar, Cristian Patrick Zeni, Tatiana Lauxen Peruzzolo, Juliana Basso Brun, Roberta Peters, André Moura Kohmann, Silzá Tramontina, Luis Augusto Rohde, Ramiro Borges Rodrigues |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology medicine.medical_specialty Bipolar Disorder Adolescent Article Subject Cross-sectional study Hippocampus Neuropsychological Tests Hippocampal formation lcsh:RC321-571 Internal medicine medicine Hipocampo Humans Bipolar disorder Cognitive decline Child lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor Transtorno bipolar Fator neurotrófico derivado do encéfalo medicine.disease Peripheral Cross-Sectional Studies Mood Neurology Female Neurology (clinical) Psychology Neuroscience Research Article |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Neural Plasticity, Vol 2015 (2015) Neural Plasticity |
| ISSN: | 2090-5904 |
| DOI: | 10.1155/2015/324825 |
| Popis: | Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents. Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|