Micro- and Nanosized Substances Cause Different Autophagy-Related Responses
| Autor: | Yu Hsuan Lee, Cai Mei Zheng, Yuh Feng Lin, Ya Yun Cheng, Hui Wen Chiu, Yung Li Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
autophagy QH301-705.5 Cell Review 010501 environmental sciences medicine.disease_cause 01 natural sciences Extracellular vesicles Catalysis Inorganic Chemistry 03 medical and health sciences Neoplasms medicine Animals Humans Particle Size Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Cell survival 030304 developmental biology 0105 earth and related environmental sciences Pollutant microparticles 0303 health sciences Chemistry Organic Chemistry Autophagy General Medicine Computer Science Applications Cell biology medicine.anatomical_structure Bioaccumulation Environmental Pollutants Particulate Matter nanoparticles Carcinogenesis extracellular vesicles |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 4787, p 4787 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | With rapid industrialization, humans produce an increasing number of products. The composition of these products is usually decomposed. However, some substances are not easily broken down and gradually become environmental pollutants. In addition, these substances may cause bioaccumulation, since the substances can be fragmented into micro- and nanoparticles. These particles or their interactions with other toxic matter circulate in humans via the food chain or air. Whether these micro- and nanoparticles interfere with extracellular vesicles (EVs) due to their similar sizes is unclear. Micro- and nanoparticles (MSs and NSs) induce several cell responses and are engulfed by cells depending on their size, for example, particulate matter with a diameter ≤2.5 μm (PM2.5). Autophagy is a mechanism by which pathogens are destroyed in cells. Some artificial materials are not easily decomposed in organisms. How do these cells or tissues respond? In addition, autophagy operates through two pathways (increasing cell death or cell survival) in tumorigenesis. Many MSs and NSs have been found that induce autophagy in various cells and tissues. As a result, this review focuses on how these particles interfere with cells and tissues. Here, we review MSs, NSs, and PM2.5, which result in different autophagy-related responses in various tissues or cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|