Soluble HLA-G molecules are released as HLA-G5 and not as soluble HLA-G1 isoforms in CSF of patients with relapsing–remitting Multiple Sclerosis
| Autor: | Massimiliano Castellazzi, Enrico Granieri, Olavio R. Baricordi, Enrico Fainardi, Maria Luisa Caniatti, Loredana Melchiorri, Maria Rosaria Tola, Marina Stignani, Roberta Rizzo, Eleonora Baldi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Gene isoform Immunology Enzyme-Linked Immunosorbent Assay Human leukocyte antigen Multiple Sclerosis Relapsing-Remitting Cerebrospinal fluid HLA Antigens medicine Humans Immunology and Allergy HLA-G Antigens medicine.diagnostic_test business.industry Multiple sclerosis Histocompatibility Antigens Class I Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Soluble hla Neurology Relapsing remitting Female Neurology (clinical) business |
| Zdroj: | Journal of Neuroimmunology. 192:219-225 |
| ISSN: | 0165-5728 |
| Popis: | Cerebrospinal fluid (CSF) levels of sHLA-G (sHLA-G1/HLA-G5) molecules and their soluble isoforms HLA-G5 and sHLA-G1 were measured by ELISA procedures in 68 relapsing-remitting Multiple Sclerosis (RR MS) patients, in 67 patients with other inflammatory neurological disorders (OIND) and in 70 subjects with non-inflammatory neurological disorders (NIND). CSF concentrations of sHLA-G1/HLA-G5 and HLA-G5 were higher in RR MS than in OIND and NIND, and in Magnetic Resonance Imaging (MRI) inactive as compared to MRI active RR MS. Our results indicate that the potential implication of sHLA-G proteins in the resolution of MS intrathecal inflammatory response is probably due to HLA-G5 isoform. |
| Databáze: | OpenAIRE |
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