Preparation and standardization of a herbal agent for the therapeutic management of asthma
| Autor: | Sabinus Ofoefule, Christiana Isimi, Martins Emeje, Olobayo O. Kunle, Amaka Izuka |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Compaction Nigeria Pharmaceutical Science Friability Dosage form Prosopis Combretaceae medicine Humans Food science Solubility Compression pressure Medicine African Traditional Dissolution Anogeissus Plants Medicinal Plant Stems biology Plant Extracts Chemistry General Medicine Prosopis africana biology.organism_classification Asthma Surgery Phytotherapy Tablets |
| Zdroj: | Pharmaceutical Development and Technology. 16:170-178 |
| ISSN: | 1097-9867 1083-7450 |
| DOI: | 10.3109/10837450903584910 |
| Popis: | This study aims to develop a suitable single tablet dosage form containing a mixture of hot water stem back extracts of Anogeissus leiocarpus and Prosopis africana (AA1), suitable for use in the therapeutic management of asthma. The compaction characteristics of the oven-dried hot water extract (HWE) were studied using the Heckel equation. The mechanical properties as well as disintegration and dissolution profile of the compacts were also assessed. The results showed that AA1 exhibited high densification due to dye filling while the subsequent rearrangement of the granules did not contribute, significantly, to their densification. The granules had enhanced plasticity as shown by the low yield point, Py. The tablets produced from the extract had good mechanical properties, with hardness increasing with compression pressure while the friability decreased. Of the four disintegrants tested, tablets containing Explotab had the shortest disintegration time of 11 min while tablets containing Prosolv had the longest disintegration time of 40 min. The order of disintegrant property is ExplotabCellactoseEmcocelMaize starchProsolv. Dissolution results (t(90%)) show that tablets containing Explotab released 100% of the drug in 20 min proving to be the most suitable in acute asthma attack. The order of dissolution is ExplotabCellactoseMaize starchProsolvEmcocel. It is concluded that incorporation of Explotab (10%w/w) as a disintegrant in AA1 preparation produced tablets of suitable compressional properties and ensured adequate drug release for the management of acute asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|