Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial

Autor:	Hannah Duggan, Annaruby Cunjamalay, Katy Sorensen, Jennifer Clark, Rebecca J. Stratton, Michelle Simpson, Catherine Casewell, Jennifer Robison, Gary P. Hubbard, Matthew Ward, Sophie Hallowes, Helen Gane, Catherine Fry, Lydia Collins, Elmarie Van Wyk, Lucy Pope, Amanda Wall
Rok vydání:	2020
Předmět:	Adult Oral 0301 basic medicine Pediatrics medicine.medical_specialty media_common.quotation_subject Pilot Projects Growth Nutrient intake law.invention Eating 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans 030212 general & internal medicine Child Nutrition media_common Paediatric patients 030109 nutrition & dietetics business.industry Malnutrition cons Pilot trial Appetite Micronutrient Low volume Paediatric Child Preschool Dietary Supplements Pediatrics Perinatology and Child Health Intake Original Article Faltering Energy Intake business
Zdroj:	European Journal of Pediatrics
ISSN:	1432-1076 0340-6199 0241-9599
DOI:	10.1007/s00431-020-03620-9
Popis:	Children with or at risk of faltering growth require nutritional support and are often prescribed oral nutritional supplements (ONS). This randomised controlled trial investigated the effects of energy-dense paediatric ONS (2.4 kcal/ml, 125 ml: cONS) versus 1.5 kcal/ml, 200 ml ONS (sONS) in community-based paediatric patients requiring oral nutritional support. Fifty-one patients (mean age 5.8 years (SD 3)) with faltering growth and/or requiring ONS to meet their nutritional requirements were randomised to cONS (n = 27) or sONS (n = 24) for 28 days. Nutrient intake, growth, ONS compliance and acceptability, appetite and gastro-intestinal tolerance were assessed. Use of the cONS resulted in significantly greater mean total daily energy (+ 531 kcal/day), protein (+ 10.1 g/day) and key micronutrient intakes compared with the sONS group at day 28 and over time, due to high ONS compliance (81% of patients ≥ 75%), maintained intake from diet alone and improved appetite in the cONS group, compared with the sONS group. Although growth increased in both intervention groups, results were significant in the cONS group (weight (p = 0.007), height (p z-score (p = 0.006)).Conclusions: This study shows that use of energy-dense (2.4 kcal/ml) low-volume paediatric-specific ONS leads to improved nutrient intakes, growth and appetite in paediatric patients requiring oral nutrition support compared with standard energy density ONS.Trial registration: The trial is registered at clinicaltrials.gov, identification number NCT02419599. What is Known:• Faltering growth is the failure of children to achieve adequate growth at a normal rate for their age and requires nutritional support, including the use of oral nutritional supplements (ONS).• Energy-dense, low-volume ONS have benefits over standard ONS in adults. What is New:• This is the first RCT to investigate the effects of energy-dense, low-volume ONS (2.4 kcal/ml, 125 ml) in children with faltering growth, showing significant improvements in total nutrient intake and increased growth.• Energy-dense, low-volume ONS can play a key role in the management of faltering growth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33086c413dcd572b13b3c1e271254a23 https://doi.org/10.1007/s00431-020-03620-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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