The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care
| Autor: | Marina De Rosa, Daniela Rega, Ugo Pace, Valeria Costabile, Paolo Delrio, Paola Izzo, Antonello Niglio, Francesca Duraturo |
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| Přispěvatelé: | DE ROSA, Marina, Rega, Daniela, Costabile, Valeria, Duraturo, Francesca, Niglio, Antonello, Izzo, Paola, Pace, Ugo, Delrio, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Tumor microenvironment business.industry Genetic heterogeneity Colorectal cancer Public health Gastroenterology Reviews Cancer Disease medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cancer cell Genotype medicine lcsh:Diseases of the digestive system. Gastroenterology colorectal cancer epidemiology colorectal cancer molecular heterogeneity colorectal cancer tumorigenesis predictive biomarkers prognostic biomarkers lcsh:RC799-869 business |
| Zdroj: | Therapeutic Advances in Gastroenterology, Vol 9 (2016) |
| Popis: | Colorectal cancer has been ranked the third and second most prevalent of all cancers in men and women, respectively, and it represents the fourth most common cause of cancer deaths. In 2012, there were 1.4 million estimated cases of colorectal cancer worldwide, and 700,000 estimated deaths, which implies significant impact on public health, especially in economically-developed countries. In recent years, there has been an increase in the number of tumors, although this has been accompanied by decreased mortality, due to more appropriate and available information, earlier diagnosis, and improvements in treatment. Colorectal cancers are characterized by great genotypic and phenotypic heterogeneity, including tumor microenvironment and interactions between healthy and cancer cells. All of these traits confer a unique peculiarity to each tumor, which can thus be considered as an individual disease. Well conducted molecular and clinical characterization of each colorectal cancer is essential with a view to the implementation of precision oncology, and thus personalized care. This last aims at standardization of therapeutic plans chosen according to the genetic background of each specific neoplasm, to increase overall survival and reduce treatment side effects. Thus, prognostic and predictive molecular biomarkers assume a critical role in the characterization of colorectal cancer and in the determination of the most appropriate therapy. |
| Databáze: | OpenAIRE |
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