High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial
| Autor: | Kenneth Smith, Brett Doleman, Bethan E. Phillips, John P. Williams, J. N. Lund, S. Williams, Philip J. Atherton, Catherine L. Boereboom, James Blackwell, A. Morton |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Cancer therapy Urology Prehabilitation High-Intensity Interval Training 030230 surgery Article Interval training 03 medical and health sciences 0302 clinical medicine Internal medicine Heart rate Humans Medicine Exercise Aged Prostate cancer Intention-to-treat analysis business.industry Preoperative Exercise Prostatic Neoplasms Cardiorespiratory fitness Patient Acceptance of Health Care Kidney Neoplasms Blood pressure Cardiorespiratory Fitness Urinary Bladder Neoplasms Oncology 030220 oncology & carcinogenesis Female Patient Safety business High-intensity interval training Anaerobic exercise |
| Zdroj: | Prostate Cancer and Prostatic Diseases |
| ISSN: | 1476-5608 1365-7852 |
| DOI: | 10.1038/s41391-020-0219-1 |
| Popis: | Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks. Subjects/patients and methods A randomised control trial of consecutive patients aged (>65 years) scheduled for major urological surgery in a large secondary referral centre in a UK hospital. The primary outcome is change in anaerobic threshold (VO2AT) following HIIT vs. standard care. Results Forty patients were recruited (mean age 72 years, male (39): female (1)) with 34 completing the protocol. Intention to treat analysis showed significant improvements in anaerobic threshold (VO2AT; mean difference (MD) 2.26 ml/kg/min (95% CI 1.25–3.26)) following HIIT. Blood pressure (BP) also significantly reduced in following: HIIT (SBP: −8.2 mmHg (95% CI −16.09 to −0.29) and DBP: −6.47 mmHg (95% CI −12.56 to −0.38)). No reportable adverse safety events occurred during HIIT and all participants achieved >85% predicted maximum heart rate during sessions, with protocol adherence of 84%. Conclusions HIIT can improve CRF and cardiovascular health, representing clinically meaningful and achievable pre-operative improvements. Larger randomised trials are required to investigate the efficacy of prehabilitation HIIT upon different cancer types, post-operative complications, socio-economic impact and long-term survival. |
| Databáze: | OpenAIRE |
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