Therapeutic potential of intravenous Xuebijing on transforming growth factor β1 and procollagen type III peptide in patients with acute paraquat poisoning
| Autor: | Nan Jiang, Xiaoli Sun, Zhongming Liu, Xuebing Zheng, Piyong Ma |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Paraquat medicine.medical_specialty Pulmonary Fibrosis Peptide Gastroenterology Group A Group B law.invention Transforming Growth Factor beta1 chemistry.chemical_compound Randomized controlled trial law Internal medicine Pulmonary fibrosis medicine Humans chemistry.chemical_classification Medicine(all) biology business.industry Poisoning Receptors transforming growth factor beta General Medicine Transforming growth factor beta Middle Aged medicine.disease Endocrinology Collagen Type III chemistry biology.protein Female Peptides business Xuebijing intravenous Transforming growth factor Drugs Chinese Herbal |
| Zdroj: | Journal of Traditional Chinese Medicine. 32(4):584-589 |
| ISSN: | 0254-6272 |
| DOI: | 10.1016/s0254-6272(13)60075-8 |
| Popis: | ObjectiveParaquat (PQ) poisoning-induced pulmonary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing therapy in PQ poisoning patients and its underlying immunomodulatory effects on transforming growth factor (TGF)-β1, and procollagen type III peptide (PIIIP) were investigated.MethodsThirty-six acute PQ poisoning patients were randomly assigned to conventional therapy (Group A) and intravenous Xuebijing administration plus conventional therapy (Group B). Twenty volunteers served as controls (Group C). Blood samples were collected upon admission (day 0) and at post-treatment days 5, 10, and 14. TGF-β1 and PIIIP concentrations were determined by ELISA and analyzed for intra- and inter-group differences over time. One-month follow-up was conducted for determining the mortality rate.ResultsTGF-β1, and PIIIP levels were significantly higher in PQ poisoning patients and increased over time (Groups A and B vs C, P |
| Databáze: | OpenAIRE |
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