Use of helminth therapy for management of ulcerative colitis and Crohn's disease: a systematic review
| Autor: | Victoria Emma Shields, Jan Cooper |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
MEDLINE Disease Biology Placebo Inflammatory bowel disease law.invention Randomized controlled trial Crohn Disease law Internal medicine Helminths medicine Animals Randomized Controlled Trials as Topic Crohn's disease Management of ulcerative colitis Incidence medicine.disease Inflammatory Bowel Diseases Ulcerative colitis R1 Infectious Diseases Animal Science and Zoology Parasitology Colitis Ulcerative |
| Zdroj: | Parasitology. 149(2) |
| ISSN: | 1469-8161 0031-1820 |
| Popis: | The incidence rate of inflammatory bowel diseases is increasing in developed countries. As such there is an increasing demand for new therapies. The aim of this systematic review was to investigate whether there is evidence to support the use of helminth therapy for the management of Crohn's disease and ulcerative colitis. Four databases (PubMed, Embase, Medline and the Cochrane Central Register of Control Trials) were searched for primary evidence in the form of clinical studies. Nine studies were suitable for inclusion: five double-blind randomized control trials and four open-label studies. This review divided the results of the studies into two categories: (a) the efficacy of helminth therapy and (b) the safety of helminth therapy. Results regarding the efficacy were mixed and a conclusive answer could not be reached, as there was not enough evidence to rule out a placebo effect. More research is needed, particularly studies with control groups to address the possibility of a placebo effect. Despite this, all nine studies concluded helminth therapy was safe and tolerable, and therefore there is currently no evidence against further exploration of this treatment option. |
| Databáze: | OpenAIRE |
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