Orthostatic Hypotension in Parkinson’s Disease: The Relation of Blood Pressure Tests and Symptoms in Daily Life

Autor:	Hein J. Verberne, Daan C. Velseboer, Rob M.A. de Bie, C. T. Paul Krediet, Rob J. de Haan, Bart Post
Přispěvatelé:	Graduate School, Intensive Care Medicine, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Methodology, Clinical Research Unit, General Internal Medicine, Nuclear Medicine, Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Neurology
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	medicine.medical_specialty Parkinson's disease business.industry Disease 030204 cardiovascular system & hematology Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Confidence interval 03 medical and health sciences Orthostatic vital signs All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Blood pressure Neurology Internal medicine Anesthesia Cohort Medicine Outpatient clinic Neurology (clinical) business Research Articles 030217 neurology & neurosurgery Cohort study
Zdroj:	Movement Disorders Clinical Practice, 4(3), 329-334. John Wiley and Sons Ltd Movement Disorders Clinical Practice, 4, 329-334 Movement Disorders Clinical Practice, 4, 3, pp. 329-334
ISSN:	2330-1619
Popis:	Background Orthostatic hypotension (OH) is common in Parkinson's disease (PD), but the relation between the results of orthostatic blood pressure tests and orthostatic symptoms in daily life is not clear. Methods We performed a cross-sectional study in an incident nontertiary care cohort of PD patients with additional recruitment of PD patients from our own outpatient clinic. We recruited sex- and age-matched controls. All participants underwent orthostatic blood pressure tests using continuous blood pressure measurements. Orthostatic symptoms experienced in daily life were assessed using autonomic symptom questionnaires (SCOPA-AUT and COMPASS-31). Results A total of 83 PD patients and 35 controls were included. Mean patient age was 69.2 years (standard deviation [SD]: 10.0). Mean disease duration was 6.6 years (SD, 0.8). The estimated prevalence of OH in PD was 24.1% (95% confidence interval: 16.2–34.3). There was no significant difference between PD patients with and without OH regarding reported daily orthostatic symptoms. Alternative OH criteria did not substantially improve this. Conclusions Perceived orthostatic symptoms in daily life have no clear association with the results of a single orthostatic blood pressure test. Better diagnostic strategies are needed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3301c416a89849f98c1c140cbf6490c4 https://doi.org/10.1002/mdc3.12415 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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