A two-generation reproduction study with transgenic Bt rice TT51 in Wistar rats
| Autor: | Xu Dong Jia, Hai Bin Xu, Zhou Yu, Jing Hu, Er Hui Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty media_common.quotation_subject Transgene Uterus Bacillus thuringiensis Physiology Spleen Genetically modified crops Biology Toxicology Pregnancy Internal medicine medicine Animals Lactation Rats Wistar Gonadal Steroid Hormones media_common Hematology Stomach Reproduction Body Weight food and beverages Oryza General Medicine Feeding Behavior Organ Size Plants Genetically Modified Small intestine Rats medicine.anatomical_structure Endocrinology Female Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 65 |
| ISSN: | 1873-6351 |
| Popis: | TT51 is a transgenic Bt rice created by fusion a synthetic CryAb/CryAc gene into rice MingHui63. A significant number of animal feeding studies with transgenic crops have been carried out with the rapid development of transgenic crops. However, the evidence is far from identifying whether certain novel transgenic crops possess potential danger for human or animal health after long-term consumption. Rice-based diets, containing 60% ordinary grocery rice, MingHui63 rice or TT51 rice by weight, were fed to two generations of male and female rats in order to determine the potential reproductive effects of TT51. In this study, both clinical performance variables and histopathological responses were examined and compared between groups. There were no significant differences between groups on body weights, food consumption, reproductive data and relative organ/body weights. There were some statistically significant differences in hematology and serum chemistry parameters, but no histological abnormalities were seen in the brain, heart, liver, spleen, kidneys, stomach, small intestine, thymus, ovaries, uterus, testes and epididymides. Based on the results, under the circumstance of this study TT51 show no significant differences on reproduction performance of rats compared with MingHui63 and the control. |
| Databáze: | OpenAIRE |
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