Theranostic biocomposite scaffold membrane
| Autor: | Conor L. Evans, Lloyd S. Miller, Roger V. Ortines, Cavin T. Mooers, Xiomara Calderon-Colon, Emmanuel Roussakis, Bret L. Pinsker |
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| Rok vydání: | 2018 |
| Předmět: |
Scaffold
Dendrimers Biophysics Bioengineering Biocompatible Materials 02 engineering and technology Theranostic Nanomedicine Diabetes Mellitus Experimental Polyethylene Glycols Biomaterials 03 medical and health sciences Mice In vivo Medicine Animals Coloring Agents 030304 developmental biology 0303 health sciences Wound Healing Membranes Tissue Scaffolds business.industry 021001 nanoscience & nanotechnology Biocompatible material Oxygen Membrane Tissue oxygenation Mechanics of Materials Ceramics and Composites Biocomposite 0210 nano-technology Wound healing business Preclinical imaging Biomedical engineering |
| Zdroj: | Biomaterials. 212 |
| ISSN: | 1878-5905 |
| Popis: | Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic information. In this study, we developed a collagen-dextran oxygen-sensing biocomposite scaffold membrane in which a phosphorescent oxygen sensor was incorporated to monitor physiological oxygen using in vivo phosphorescence imaging in a preclinical mouse model of wound healing. The oxygen-sensing biocomposite scaffold membrane enabled the noninvasive and longitudinal monitoring of oxygenation changes in vivo in an approach compatible with commercially available preclinical in vivo imaging system instruments. This study provides a new and novel capability where a biocomposite material can serve as a biocompatible, biodegradable theranostic platform to promote and assess tissue oxygenation during wound healing. |
| Databáze: | OpenAIRE |
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