Structural measurements and cell line studies of the copper–PEG–Rifampicin complex against Mycobacterium tuberculosis
| Autor: | Thomas, Manning, Rachel, Mikula, Greg, Wylie, Dennis, Phillips, Jackie, Jarvis, Fengli, Zhang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Magnetic Resonance Spectroscopy
Organic Chemistry Clinical Biochemistry Antitubercular Agents Pharmaceutical Science Microbial Sensitivity Tests Mycobacterium tuberculosis Biochemistry Polyethylene Glycols Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Drug Discovery Molecular Medicine Rifampin Molecular Biology Copper |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:451-458 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2014.12.053 |
| Popis: | The bacterium responsible for tuberculosis is increasing its resistance to antibiotics resulting in new multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). In this study, several analytical techniques including NMR, FT-ICR, MALDI-MS, LC-MS and UV/Vis are used to study the copper-Rifampicin-Polyethylene glycol (PEG-3350) complex. The copper (II) cation is a carrier for the antibiotic Rifampicin as well as nutrients for the bacterium. The NIH-NIAID cell line containing several Tb strains (including antibiotic resistant strains) is tested against seven copper-PEG-RIF complex variations. |
| Databáze: | OpenAIRE |
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