Is an instrumented spasticity assessment an improvement over clinical spasticity scales in assessing and predicting the response to integrated botulinum toxin type A treatment in children with cerebral palsy?
| Autor: | Britt Vandendoorent, Catherine Huenaerts, Kaat Desloovere, Lynn Bar-On, Guy Molenaers, Angela Nieuwenhuys, Anja Van Campenhout, Erwin Aertbeliën |
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| Přispěvatelé: | Rehabilitation medicine, Amsterdam Movement Sciences - Restoration and Development |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic medicine.diagnostic_test business.industry Modified Ashworth scale Rehabilitation Physical Therapy Sports Therapy and Rehabilitation Electromyography medicine.disease Cerebral palsy law.invention Physical medicine and rehabilitation Spastic cerebral palsy Randomized controlled trial law Physical therapy Medicine Spasticity medicine.symptom business Range of motion |
| Zdroj: | Archives of Physical Medicine and Rehabilitation, 95(3), 515-523. W.B. Saunders Ltd Bar-On, L, Van Campenhout, A, Desloovere, K, Aertbeliën, E, Huenaerts, C, Vandendoorent, B, Nieuwenhuys, A & Molenaers, G 2014, ' Is an instrumented spasticity assessment an improvement over clinical spasticity scales in assessing and predicting the response to integrated botulinum toxin type A treatment in children with cerebral palsy? ', Archives of Physical Medicine and Rehabilitation, vol. 95, no. 3, pp. 515-523 . https://doi.org/10.1016/j.apmr.2013.08.010 |
| ISSN: | 0003-9993 |
| Popis: | Objective To compare responsiveness and predictive ability of clinical and instrumented spasticity assessments after botulinum toxin type A (BTX) treatment combined with casting in the medial hamstrings (MEHs) in children with spastic cerebral palsy (CP). Design Prospective cohort study. Setting Hospital. Participants Consecutive sample of children (N=31; 40 MEH muscles) with CP requiring BTX injections. Intervention Clinical and instrumented spasticity assessments before and on average ± SD 53±14 days after BTX. Main Outcome Measures Clinical spasticity scales included the Modified Ashworth Scale and the Modified Tardieu Scale. The instrumented spasticity assessment integrated biomechanical (position and torque) and electrophysiological (surface electromyography) signals during manually performed low- and high-velocity passive stretches of the MEHs. Signals were compared between both stretch velocities and were examined pre- and post-BTX. Responsiveness of clinical and instrumented assessments was compared by percentage exact agreement. Prediction ability was assessed with a logistic regression and the area under the receiver operating characteristic (ROC) curves of the baseline parameters of responders versus nonresponders. Results Both clinical and instrumented parameters improved post-BTX ( P ≤.005); however, they showed a low percentage exact agreement. The baseline Modified Tardieu Scale was the only clinical scale predictive for response (area under the ROC curve=0.7). For the instrumented assessment, baseline values of root mean square (RMS) electromyography and torque were better predictors for a positive response (area under the ROC curve=.82). Baseline RMS electromyography remained an important predictor in the logistic regression. Conclusions The instrumented spasticity assessment showed higher responsiveness than the clinical scales. The amount of RMS electromyography is considered a promising parameter to predict treatment response. |
| Databáze: | OpenAIRE |
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