Relationship among interthalamic adhesion size, thalamic anatomy and neuropsychological functions in healthy volunteers
Autor: | Pamela DeRosse, Anil K. Malhotra, Majnu John, Nishad R Damle, Toshikazu Ikuta, Philip R. Szeszko, Bart D. Peters |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Histology Adolescent Thalamus Article 050105 experimental psychology White matter Young Adult 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Humans 0501 psychology and cognitive sciences Child Aged Sex Characteristics Interthalamic adhesion medicine.diagnostic_test General Neuroscience 05 social sciences Age Factors Neuropsychology Reproducibility of Results Magnetic resonance imaging Anatomy Middle Aged Magnetic Resonance Imaging White Matter Healthy Volunteers Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging medicine.anatomical_structure Bridge (graph theory) Female Psychology 030217 neurology & neurosurgery Diffusion MRI |
Zdroj: | Brain Structure and Function. 222:2183-2192 |
ISSN: | 1863-2661 1863-2653 |
Popis: | The interthalamic adhesion (ITA) is an understudied neuroanatomical structure that forms a bridge of tissue connecting the thalamus of each hemisphere across the midline whose functional significance remains largely unknown. The likelihood of ITA absence has been reported in some studies to be increased in males, but findings have been inconsistent. We used magnetic resonance imaging to investigate the size and absence of the ITA and their relationship to thalamic volume, putative indices of white matter integrity (fractional anisotropy and mean diffusivity) within the anterior thalamic radiation and neuropsychological functions in 233 (129M/104F) healthy volunteers (age range = 8 to 68). To ensure high reliability in this study 2 operators independently rated the absence of the ITA and measured its size for all individuals. The ITA was absent in 4% of all individuals with no sex differences in its absence. Females had greater ITA size compared to males overall with both groups demonstrating nonlinear age-associated changes across the age range examined. ITA size among females correlated significantly with thalamus volume and lower mean diffusivity in the anterior thalamic radiation. Path modeling indicated that ITA size statistically mediated the relationship between age and attention among females. Our findings provide evidence for sex differences in ITA size across the lifespan, which are associated with the surrounding thalamic anatomy and neuropsychological functions. |
Databáze: | OpenAIRE |
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