Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life
| Autor: | Mamak Shariat, Hosein Dalili, Soja Ziaei, Fatemeh Nayeri, Alireza Abdollahi, Masoumeh Asgarshirazi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Helicobacter pylori infection
Pediatrics medicine.medical_specialty biology business.industry Transmission (medicine) lcsh:RJ1-570 Breastfeeding lcsh:Pediatrics Helicobacter pylori biology.organism_classification Mixed feeding Serology 03 medical and health sciences 0302 clinical medicine Pediatrics Perinatology and Child Health Cohort Population study Medicine 030211 gastroenterology & hepatology 030212 general & internal medicine business |
| Zdroj: | Journal of Comprehensive Pediatrics, Vol 8, Iss 4 (2017) |
| ISSN: | 2251-8177 2251-8150 |
| DOI: | 10.5812/compreped.59992 |
| Popis: | Background Helicobacter pylori is a common gastrointestinal pathogen in human. The mechanism of its acquisition and transmission is unclear, although the most likely mode of transmission is fecal-oral or oral-oral. Most of infections occur in childhood. The current cohort assessed the prevalence of infection in infants with different feeding strategies (exclusive breastfeeding, formula, or mixed feeding). Methods The current study was carried out in Vali-Asr hospital of Imam Khomeini hospital complex, Tehran, Iran, from 2012 to 2015.The study population included infants born in this hospital and registered in breastfeeding research center during the first 6 months of life. They were compared in 2 groups; exclusively breastfed, and formula or mixed fed. Mothers’ H. pylori infection was checked serologically using the enzyme-linked immunosorbent assay (ELISA) technique and those of infants by monoclonal antibody test using ELISA technique on stool samples at 1st and 6th month of life. Results A total of 102 infants in 2 groups (54 exclusively breastfed and 48 formula or mixed fed) completed the study. Mothers’ serological assessments were positive in 68% of exclusively breast-fed subjects and 60% of formula or mixed fed subjects. All 1-month-old infants were negative for the infection and in the 6-month-old infants 10 cases (18.5%) were positive, 1 case was at borderline in the exclusively breastfed, and 13 cases (27%) were positive in formula- or mixed-fed subjects. This difference was not statistically significant (P = 0.302). The Mantel-Hanzel test was used to find a relationship in H. pylori positivity in mothers and infants during the first 6-month of life in each of the 2 groups. It was found that out of 37 serologically positive mothers in the breastfed group, 8 infants (22%) were H. pylori positive and in the formula and mixed-fed group, of 29 serologically positive mothers 10 infants (34%) were also H. pylori positive, but the difference between the groups was not statistically significant (P = 0.727). It meant that the prevalence of infantile H. pylori infection was similar in the 2 groups. Conclusions The current study findings showed that exclusive breastfeeding had no role in protection or facilitation of H. pylori infection. |
| Databáze: | OpenAIRE |
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