Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors
| Autor: | Pipsa Saharinen, Kirsi Paukku, Panu E. Kovanen, Kati Takaluoma, Olli Silvennoinen |
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| Rok vydání: | 1997 |
| Předmět: |
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Molecular Microbiology (medical) Receptor tyrosine kinase Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Immunology and Allergy Receptors Cytokine 030304 developmental biology 0303 health sciences biology Janus kinase 1 JAK-STAT signaling pathway Tyrosine phosphorylation General Medicine Protein-Tyrosine Kinases Glycoprotein 130 3. Good health DNA-Binding Proteins Gene Expression Regulation chemistry Tyrosine kinase 2 030220 oncology & carcinogenesis Trans-Activators biology.protein Cancer research Cytokine receptor Janus kinase Signal Transduction |
| Zdroj: | ResearcherID |
| ISSN: | 1600-0463 0903-4641 |
| DOI: | 10.1111/j.1699-0463.1997.tb05047.x |
| Popis: | Cytokines are the principal regulators of cell proliferation and differentiation of hematopoietic cells and these responses are initiated through activation of hematopoietic cytokine receptors. Although the receptor intracellular domains lack any kinase domains, activation of cytokine receptors lead to rapid induction of tyrosine phosphorylation. Recently, cytokine receptors have been shown to associate with and activate members of the cytoplasmic Jak tyrosine kinase family. Activation of Jak kinases leads to phosphorylation of several signaling proteins and thereby couples ligand-mediated receptor stimulation to activation of intracellular signaling pathways. The best characterized substrates for Jaks are the Stat transcription factors, which are crucial mediators of cytokine-mediated gene responses, and, particularly, central determinants for the specificity in cytokine responses. |
| Databáze: | OpenAIRE |
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