Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice
| Autor: | Rosa Maria Esteves Arantes, Priscila T. T. Bernardes, Bárbara M. Rezende, Vanessa Pinho, Mauro M. Teixeira, Danielle G. Souza, Carolina B. Resende, Marina G. M. Castor, Fernão Castro Braga |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Chemokine
GVHD Anti-Inflammatory Agents Pharmaceutical Science CCL3 Graft vs Host Disease Biology CCL5 Article Proinflammatory cytokine Cell Line 03 medical and health sciences Mice 0302 clinical medicine Drug Discovery Splenocyte medicine cytokine Cell Adhesion Leukocytes Animals Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 030304 developmental biology algae Inflammation 0303 health sciences Liver Diseases Macrophages chemokine Endothelial Cells medicine.disease inflammation 3. Good health Intestines Mice Inbred C57BL Disease Models Animal Graft-versus-host disease lcsh:Biology (General) 030220 oncology & carcinogenesis Immunology Rhodophyta biology.protein Cytokines Tumor necrosis factor alpha Intravital microscopy |
| Zdroj: | Marine Drugs Marine Drugs, Vol 11, Iss 7, Pp 2595-2615 (2013) Marine Drugs; Vol 11 Marine Drugs; Volume 11; Issue 7; Pages: 2595-2615 |
| ISSN: | 1660-3397 |
| Popis: | Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment. |
| Databáze: | OpenAIRE |
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