| Autor: |
Carlos Rocha-de-Lossada, Carmen Alba Linero, Álvaro Santos Ortega, Marina Rodríguez Calvo-de-Mora, Rahul Rachwani, Davide Borroni, Emilio Alba, Manuel Benavides Orgaz, Vito Romano |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Arquivos Brasileiros de Oftalmologia (2021) |
| ISSN: |
0004-2749 |
| DOI: |
10.5935/0004-2749.2022-0039 |
| Popis: |
The purpose of this study is to report the clinical features and outcomes of ocular surface toxicity following depatuxizumab mafoditin (ABT-414) therapy for unresectable glioblastoma. Ocular signs and symptoms of three patients treated with ABT-414 during a phase III trial for glioblastoma multiforme were evaluated. Both eyes of all patients were damaged during the week after the first infusion of the ABT-414 molecule. In all patients, mild-to-moderate keratitis could be ascertained, along with decreased visual acuity and blurred vision, as well as foreign-body sensation and redness. Symptoms and visual acuity improved 4 weeks. In conclusion, ABT-414 therapy may cause transient ocular surface toxicity. The initiation of artificial tears and lubricant ointment was enough to control the ocular surface signs and symptoms. A multidisciplinary approach, complete ophthalmologic monitorization, and elaboration of protocols are required to adequately manage these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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