Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation
| Autor: | Qulsoom Hussain, Kamran Ilyas, Zarak H Khan, Muhammad Yasir, Rizwan Asim, Haider Ghazanfar, Faisal Inayat, Hamza Hassan Khan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Physical examination Malignancy chemotherapy 03 medical and health sciences 0302 clinical medicine unresectable sarcoma Internal medicine Biopsy medicine Undifferentiated (Embryonal) Sarcoma Internal Medicine Basic metabolic panel Chemotherapy medicine.diagnostic_test business.industry General Engineering Gastroenterology Complete blood count medicine.disease undifferentiated embryonal sarcoma of liver liver transplant 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Radiology uesl Liver function tests business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Undifferentiated embryonal sarcoma of the liver (UESL) is a malignancy of mesenchymal origin observed predominantly in the pediatric population and very rarely in adults. We describe the case of a 21-year-old male who presented with acute onset of right upper quadrant pain and distention. Physical examination of the patient revealed right upper quadrant tenderness with the lower border of the liver palpable, 4 cm below the right costal margin. Laboratory tests performed on admission showed that the patient's liver function tests, urinalysis, complete blood count, and basic metabolic panel were within reference range. The levels of viral hepatitis and tumor serum markers were all within normal limits except for an elevated level of cancer antigen (CA) 19-9. Magnetic resonance imaging (MRI) and a computerized tomography (CT) scan showed two well-circumscribed lesions in the right lobe. The biopsy of the lesion showed UESL. The patient was started on chemotherapy. On his fifth cycle of chemotherapy, the patient was offered orthotopic liver transplantation (OLT). The patient underwent a successful OLT. There were no postoperative complications. Increased survival time and prevention of the recurrence of USEL can be achieved by surgical resection of the tumor combined with adjuvant and neoadjuvant chemotherapy. For unresectable tumors, OLT with chemotherapy can be a potential cure in younger patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|