Dysfunction of immune system in the development of large granular lymphocyte leukemia
| Autor: | Lili Yang, Sheng Wei, Houfang Sun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Neutrophils Lymphocyte medicine.medical_treatment chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Neutropenia Targeted therapy 03 medical and health sciences 0302 clinical medicine Antigenic stimulation Immune system Humans Medicine Large Granular Lymphocyte Leukemia B-Lymphocytes business.industry Hematology medicine.disease Killer Cells Natural Leukemia Large Granular Lymphocytic Leukemia medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female Lymphoproliferative disease business Signal Transduction 030215 immunology |
| Zdroj: | Hematology. 24:139-147 |
| ISSN: | 1607-8454 |
| Popis: | Large granular lymphocyte (LGL) leukemia is a rare type of lymphoproliferative disease caused by clonal antigenic stimulation of T cells and natural killer (NK) cells.In this review, we focus on the current knowledge of the immunological dysfunctions associated with LGL leukemia and the associated disorders coexistent with this disease. Novel therapeutic options targeting known molecular mechanisms are also discussed.The pathogenesis of LGL leukemia involves the accumulation of gene mutations, dysregulated signaling pathways and immunological dysfunction. Mounting evidence indicated that dysregulated survival signaling pathways may be responsible for the immunological dysfunction in LGL leukemia including decreased numbers of neutrophils, dysregulated signal transduction of NK cells, abnormal B-cells, aberrant CD8+ T cells, as well as autoimmune and hematological abnormalities.A better understanding of the immune dysregulation triggered by LGL leukemia will be beneficial to explore the pathogenesis and potential therapeutic targets for this disease. |
| Databáze: | OpenAIRE |
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