Effects of a Cysteinyl Leukotriene Dual 1/2 Receptor Antagonist on Antigen-Induced Airway Hypersensitivity and Airway Inflammation in a Guinea Pig Asthma Model
| Autor: | Hiroyuki Sano, Masato Muraki, Yuji Tohda, Hiroshi Santo, Ryuji Sato, Takashi Iwanaga, Shu Imbe |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cyclopropanes
Male Leukotriene D4 Ovalbumin medicine.drug_class Guinea Pigs Immunology Acetates Sulfides Bronchial Provocation Tests chemistry.chemical_compound Animals Immunology and Allergy Medicine Lung Montelukast Inflammation Receptors Leukotriene Leukotriene E4 biology Leukotriene receptor business.industry General Medicine respiratory system Eosinophil Receptor antagonist Acetylcholine Asthma respiratory tract diseases Eosinophils medicine.anatomical_structure chemistry Eicosanoid Quinolines biology.protein Leukotriene Antagonists SRS-A Bronchial Hyperreactivity business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | International Archives of Allergy and Immunology. 155:90-95 |
| ISSN: | 1423-0097 1018-2438 |
| Popis: | Background: Little is known about the role of the cysteinyl leukotriene (cysLT) 2 receptor in the pathophysiology of asthma. The aim of this study is to investigate the effects of a cysLT1 receptor antagonist (montelukast) and a dual cysLT1/2 receptor antagonist (BAY-u9773) on airway hypersensitivity and airway inflammation induced by antigen challenge in ovalbumin (OVA)-sensitized guinea pigs. Methods: Male Hartley guinea pigs sensitized with OVA were intraperitoneally administered 0.1, 1, or 10 mg/kg of montelukast or 0.1 mg/kg of BAY-u9773 and then challenged with inhaled OVA. Airway reactivity to acetylcholine, inflammatory cells in bronchoalveolar lavage (BAL) fluid, and eosinophil infiltration in airway walls after OVA challenge were evaluated. Results: Pretreatment with 1 or 10 mg/kg, but not 0.1 mg/kg, of montelukast significantly suppressed airway hypersensitivity and eosinophil infiltration into the BAL fluid. Moreover, 0.1 mg/kg of BAY-u9773 significantly suppressed the development of these markers. The suppressive effects of BAY-u9773, although not significantly different, trended toward being greater than those of montelukast. Although all of the doses of montelukast tested and 0.1 mg/kg of BAY-u9773 significantly suppressed eosinophil infiltration in airway walls, the suppressive effect of BAY-u9773 was significantly greater than that of 0.1 mg/kg of montelukast. Conclusion: Signaling may contribute to the pathophysiology of asthma via the cysLT1/2 receptor. |
| Databáze: | OpenAIRE |
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