Synthesis of Methyl 5(6)-(4-Aminophenoxy)- and 5(6)-(2-Aminophenoxy)-2-benzimidazolyl Carbamates and Their Biological Properties

Autor:	T. P. Vorobyeva, V. M. Kosareva, G. E. Chikisheva, E. V. Klimakova, G. V. Kiseleva, V. S. Pilyugin, A. N. Mikhailyuk, S. L. Kuznetsova
Rok vydání:	2005
Předmět:	Molar Acetic acid chemistry.chemical_compound Chemistry Biological property Organic Chemistry Toxicity Organic chemistry General Medicine
Zdroj:	ChemInform. 36
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200514133
Popis:	A procedure was developed for preparation of methyl 5(6)-(4-aminophenoxy)- and 5(6)-(2-aminophenoxy)-2-benzimidazolyl carbamates by reaction of 3,4,4`-triaminodiphenyl or 3,4,2`-triaminodiphenyl ethers respectively with methyl cyanocarbamate in water solution in the presence of 7-10 molar excess of acetic acid. The helminthicidal properties, embryotoxicity, and overall toxicity of compounds obtained were estimated.
Databáze:	OpenAIRE
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