Development of an effective whole-spore vaccine to protect against microsporidial gill disease in rainbow trout (Oncorhynchus mykiss) by using a low-virulence strain of Loma salmonae
| Autor: | N. J. Guselle, David J. Speare, R. J. F. Markham |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Gill Gills endocrine system animal structures Time Factors medicine.medical_treatment Clinical Biochemistry Immunology Spores Protozoan Fisheries Virulence Administration Oral Biology Microsporidiosis Microbiology Fish Diseases medicine Immunology and Allergy Animals Vaccines Strain (chemistry) fungi medicine.disease biology.organism_classification Vaccine Research Spore Specific Pathogen-Free Organisms Trout Oncorhynchus mykiss Loma Rainbow trout Adjuvant |
| Zdroj: | Clinical and vaccine immunology : CVI. 14(12) |
| ISSN: | 1556-679X |
| Popis: | In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit microsporidial gill disease in trout, we found that fish receiving 10 3 to 10 5 killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian. |
| Databáze: | OpenAIRE |
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