From Loops to Looks: Transcription Factors and Chromatin Organization Shaping Terminal B Cell Differentiation
Autor: | Almudena R. Ramiro, Maribel Parra, Biola M. Javierre, Ester Marina-Zárate, Alba Azagra |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Immunology Biology Epigenesis Genetic 03 medical and health sciences B lymphopoiesis 0302 clinical medicine medicine Immunology and Allergy Animals Humans Epigenetics Gene Transcription factor B cell B-Lymphocytes Lymphopoiesis Germinal center Cell Differentiation Chromatin Cell biology 030104 developmental biology medicine.anatomical_structure Terminal (electronics) 030215 immunology Transcription Factors |
Zdroj: | Trends in immunology. 41(1) |
ISSN: | 1471-4981 |
Popis: | B lymphopoiesis is tightly regulated at the level of gene transcription. In recent years, investigators have shed light on the transcription factor networks and the epigenetic machinery involved at all differentiation steps of mammalian B cell development. During terminal differentiation, B cells undergo dramatic changes in gene transcriptional programs to generate germinal center B cells, plasma cells and memory B cells. Recent evidence indicates that mature B cell formation involves an essential contribution from 3D chromatin conformations through its interplay with transcription factors and epigenetic machinery. Here, we provide an up-to-date overview of the coordination between transcription factors, epigenetic changes, and chromatin architecture during terminal B cell differentiation, focusing on recent discoveries and technical advances for studying 3D chromatin structures. |
Databáze: | OpenAIRE |
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