Disuniting Uniformity: A Pied Cladistic Canvas of mtDNA Haplogroup H in Eurasia
| Autor: | Erwan Pennarun, M. V. Golubenko, Marijana Peričić, Pavao Rudan, Boris Malyarchuk, Mireille Claustres, Oleg Balanovsky, Urmas Roostalu, Helle Viivi Tolk, Toomas Kivisild, Christelle Richard, Lovorka Barać, V. P. Puzyrev, Maere Reidla, Esien Usanga, Elena Grechanina, Nicholas P. Anagnou, Richard Villems, Vladislava Gusar, Vadim Stepanov, Miroslava Derenko, Sirle Laos, Kalliopi I. Pappa, Ilia Mikerezi, Jüri Parik, Emmanuel Michalodimitrakis, Eva Liis Loogväli, Mukaddes Gölge, E. K. Khusnutdinova, Andre Chaventre, Ene Metspalu, Elena Balanovska, Arina Lunkina, Jean Paul Moisan, Kristiina Tambets |
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| Rok vydání: | 2004 |
| Předmět: |
Mitochondrial DNA
Asia Haplogroup H Population Mothers Biology DNA Mitochondrial Haplogroup Evolution Molecular Monophyly human mitochondrial DNA population genetics phylogeography Phylogenetics Ethnicity Genetics Humans education Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics education.field_of_study Geography Models Genetic Phylogenetic tree Haplotype Genetic Variation Gene Pool Europe Genetics Population Haplotypes Evolutionary biology Multigene Family Mutation Female |
| Zdroj: | Molecular Biology and Evolution. 21:2012-2021 |
| ISSN: | 1537-1719 0737-4038 |
| DOI: | 10.1093/molbev/msh209 |
| Popis: | It has been often stated that the overall pattern of human maternal lineages in Europe is largely uniform. Yet this uniformity may also result from an insufficient depth and width of the phylogenetic analysis, in particular of the predominant western Eurasian haplogroup H that comprises nearly a half of the European mitochondrial DNA (mtDNA) pool. Making use of the coding sequence information from 267 mtDNA haplogroup (Hg) H sequences, we have analyzed 830 mtDNA genomes, from 11 European, Near and Middle Eastern, Central Asian and Altaian populations. In addition to the seven previously specified sub-haplogroups, we define fifteen novel sub-clades of Hg H present in the extant human populations of western Eurasia. The refinement of the phylogenetic resolution has allowed us to resolve a large number of homoplasies in phylogenetic trees of Hg H based on the first hypervariable segment (HVS-I) of mtDNA. As many as 50 out of 125 polymorphic positions in HVS-I were found to be mutated in more than one sub-cluster of Hg H. The phylogeographic analysis revealed that sub-Hgs H1(*), H1b, H1f, H2a, H3, H6a, H6b and H8 demonstrate distinct phylogeographic patterns. The monophyletic sub-haplogroups of Hg H provide means for further progress in the understanding of the (pre)historic movements of women in Eurasia and for the understanding of the present-day genetic diversity of western Eurasians in general. |
| Databáze: | OpenAIRE |
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