Rho GTPases are Involved on Regulation of Cytodifferentiation of SCC-4 Oral Squamous Cell Carcinoma Cell Line: A Preliminary Study
| Autor: | Virgínia Oliveira Crema, Nanci M Pineiro, Anna Cecília Dias Maciel Carneiro |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
rho GTP-Binding Proteins
0301 basic medicine Cytodifferentiation Short Communication Confocal Bacterial Toxins Clostridium difficile toxin A Vimentin macromolecular substances Immunofluorescence 03 medical and health sciences Cytokeratin 0302 clinical medicine Bacterial Proteins Cell Line Tumor Rho GTPases medicine Humans biology medicine.diagnostic_test Chemistry Cell Differentiation General Medicine Clostridium difficile Molecular biology Actins Staining oral squamous cell carcinoma stomatognathic diseases 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Carcinoma Squamous Cell biology.protein Mouth Neoplasms |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2020.21.1.3 |
| Popis: | Objective: This study evaluated the involvement of Rho GTPases proteins in the regulation of cytodifferentiation of the SCC-4 human oral squamous cell carcinoma cell line. Methods: Cytokeratin and vimentin immunofluorescence and F-actin staining, assays were performed with control cells and Clostridium difficile 1, 2 and 4 μg/mL Toxin A (Rho GTPases inhibitor) treated SCC-4 cells on three-dimensional MatrigelTM for 24 h. Samples were analyzed by using confocal laser microscopy. Significances were p |
| Databáze: | OpenAIRE |
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