Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers
| Autor: | Joseph W. Ditre, Lisa R. LaRowe, Martin J. De Vita, Jesse D. Kosiba, Emily L. Zale |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Nicotine medicine.medical_specialty medicine.medical_treatment Psychological intervention 030508 substance abuse Article law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Biological Psychiatry Pain Measurement Neurogenic inflammation Smokers Pain Perception Tobacco Use Disorder Middle Aged medicine.disease Drug Abstinence Substance Withdrawal Syndrome Clinical Psychology Psychiatry and Mental health Nicotine withdrawal Hyperalgesia Smoking cessation Female Neurogenic Inflammation medicine.symptom 0305 other medical science Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Abnormal Psychology. 127:578-589 |
| ISSN: | 1939-1846 0021-843X |
| Popis: | An evolving reciprocal model posits that pain and tobacco smoking behavior interact in the manner of a positive feedback loop, resulting in greater pain and the maintenance of nicotine dependence. There is also reason to believe that abstaining from smoking may increase pain during the early stages of smoking cessation. The goal of this study was to test the effects of nicotine deprivation on experimental pain reactivity. Daily tobacco cigarette smokers (N = 165; 43% female) were randomized to either extended nicotine deprivation (12-24 hr smoking abstinence), minimal deprivation (2 hr smoking abstinence), or continued smoking conditions, prior to undergoing pain induction via topical capsaicin. As hypothesized, results indicated that extended deprivation (relative to continued smoking) increased capsaicin-induced pain intensity ratings, neurogenic inflammation, and mechanical hyperalgesia, thus implicating both central and peripheral mechanisms of action in the effects of smoking abstinence on pain reactivity. Pain intensity ratings were also positively correlated with nicotine withdrawal symptoms, and exploratory analyses suggest that pain sensitivity may increase with duration of smoking abstinence. Collectively, these findings indicate that smokers may experience a variety of negative pain-related sequelae during the early stages of a quit attempt. Future research should examine pain as a consequence or correlate of the nicotine withdrawal syndrome, and determine whether smokers may benefit from tailored cessation interventions that account for nicotine deprivation-induced amplification of pain. (PsycINFO Database Record |
| Databáze: | OpenAIRE |
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