Growth rate of coeliac children is compromised before the onset of the disease
| Autor: | Caroline Meijer, Judith Gyimesi, Sybille Koletzko, Riccardo Troncone, Donatella Cielo, Alfredo Chiurazzi, Renata Auricchio, Sanja Kolaček, Corina Hartman, Malgoscia Pieścik-Lech, Martina Galatola, Ilma Rita Korponay-Szabó, Hania Szajewska, Dario Bruzzese, Carmen Ribes-Koninckx, Gemma Castilljeo, M. L. Mearin, Raanan Shamir, Paula Crespo Escobar, Isabel Polanco, Pio Stellato, Luigi Greco |
|---|---|
| Přispěvatelé: | Auricchio, Renata, Stellato, Pio, Bruzzese, Dario, Cielo, Donatella, Chiurazzi, Alfredo, Galatola, Martina, Castilljeo, Gemma, Crespo Escobar, Paula, Gyimesi, Judith, Hartman, Corina, Kolacek, Sanja, Koletzko, Sybille, Korponay-Szabo, Ilma, Mearin, Maria Luisa, Meijer, Caroline, Pieścik-Lech, Malgoscia, Polanco, Isabel, Ribes-Koninckx, Carmen, Shamir, Raanan, Szajewska, Hania, Troncone, Riccardo, Greco, Luigi |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty growth gastroenterology Disease Coeliac disease Serology 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Growth rate Longitudinal Studies Genetic risk paediatric practice Child Growth Disorders business.industry Body Weight Infant Newborn Infant medicine.disease Body Height Celiac Disease Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Female business gastroenterology growth paediatric practice Rate of growth |
| Zdroj: | ARCHIVES OF DISEASE IN CHILDHOOD r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Archives of Disease in Childhood, 105(10), 964-968. BMJ PUBLISHING GROUP |
| ISSN: | 0003-9888 |
| Popis: | IntroductionGrowth impairment has often been described in children who develop coeliac disease (CD). Based on data from the multicentre, longitudinal PreventCD study, we analysed the growth patterns of infants at genetic risk of CD, comparing those who developed CD by 6 years of age (CD ‘cases’, 113 infants) versus those who did not develop CD by 6 years (no CD ‘controls’, 831 infants).MethodsWeight and length/height were measured using a longitudinal protocol. Raw measurements were standardised, computing z-scores for length/height and weight; a linear mixed model was fitted to the data in order to compare the rate of growth in the two cohorts.ResultsNeither cases nor controls had significant growth failure. However, when the mean z-scores for weight and height were analysed, there was a difference between the two groups starting at fourth month of life. When the growth pattern in the first year was analysed longitudinally using mixed models, it emerged that children who develop CD had a significantly lower growth rate in weight z-score (−0.028/month; 95% CI −0.038 to −0.017; pConclusionThe growth of children at risk of CD rarely fell below ‘clinical standards’. However, growth rate was significantly lower in cases than in controls. Our data suggest that peculiar pathways of growth are present in children who develop CD, long before any clinical or serological signs of the disease appear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|