Benefit of Treating Hepatocellular Carcinoma Recurrence after Liver Transplantation and Analysis of Prognostic Factors for Survival in a Large Euro-American Series
| Autor: | D. Davidson, Anand Ghanekar, Luis Castells, Mireia Caralt, Gonzalo Sapisochin, Cristina Dopazo, Jerome M. Laurence, Ehab Rafael, Ramón Charco, Charbel Sandroussi, J. L. Lazaro, Nicolas Goldaracena, Les Lilly, Paul D. Greig, Itxarone Bilbao, David R. Grant, M. S. Cattral, Markus Selzner, Ian D. McGilvray, S. Astete |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Intention Liver transplantation Gastroenterology Young Adult Postoperative Complications Risk Factors Internal medicine Carcinoma Medicine Humans Prospective Studies Prospective cohort study Survival rate Aged Neoplasm Staging Retrospective Studies business.industry Incidence Hazard ratio Liver Neoplasms Retrospective cohort study Middle Aged medicine.disease Prognosis Confidence interval United States Liver Transplantation Europe Survival Rate Oncology Hepatocellular carcinoma Multivariate Analysis Catheter Ablation Surgery Female alpha-Fetoproteins Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Annals of surgical oncology. 22(7) |
| ISSN: | 1534-4681 |
| Popis: | To identify prognostic factors after hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). We retrospectively reviewed the combined experience at Toronto General Hospital and Hospital Vall d’Hebron managing HCC recurrence after LT (n = 121) between 2000 and 2012. We analyzed prognostic factors by uni- and multi-variate analysis. Median follow-up from LT was 29.5 (range 2–129.4) months. Median follow-up from HCC recurrence was 12.2 (range 0.1–112.5) months. At recurrence, 31.4 % were treated with curative-intent treatments (surgery or ablation), 42.1 % received palliative treatment, and 26.4 % received best supportive care. The 1-, 3-, and 5-year survivals, respectively, after HCC recurrence were 75, 60, and 31 %, vs. 60, 19, and 12 %, vs. 52, 4, and 5 % (p |
| Databáze: | OpenAIRE |
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