Low plasma 25-hydroxyvitamin D levels are associated with an increased risk of depressive symptoms in community-dwelling Japanese people aged between 40 and 74 years: The Murakami cohort study

Autor: Aya, Hinata, Kaori, Kitamura, Yumi, Watanabe, Keiko, Kabasawa, Toshiko, Saito, Akemi, Takahashi, Ribeka, Takachi, Ryosaku, Kobayashi, Rieko, Oshiki, Masayuki, Iki, Shoichiro, Tsugane, Ayako, Sasaki, Kei, Watanabe, Kazutoshi, Nakamura
Rok vydání: 2023
Předmět:
Zdroj: Journal of Affective Disorders. 325:48-54
ISSN: 0165-0327
Popis: Association between vitamin D levels and the occurrence of depression are not always consistent. The present cohort study aimed to determine this association in older adults, using a method for measuring vitamin D levels which is more accurate than those used in previous studies.Participants were 3447 individuals aged 40-74 years without depressive symptoms at baseline who participated in the 5-year follow-up survey. The baseline investigation, including a self-administered questionnaire survey and blood collection, was conducted in 2011-2013. Plasma 25-hydroxyvitamin D (25[OH]D) levels were measured, and divided into overall quartiles summed up by sub-quartiles and stratified by age, sex, and season. The outcome was depressive symptoms determined by the CES-D (11-item, cut-off score of 6/7) 5 years later. Covariates were demographics, lifestyles, baseline CES-D score, and disease history.Mean plasma 25(OH)D levels were 58.0 nmol/L in men and 45.7 in women (P 0.0001), and cumulative incidences of depressive symptoms were 249/1577 (15.8 %) in men and 313/1870 (16.7 %) in women (P = 0.4526). The lower 25(OH)D quartile group had higher adjusted ORs in men and women combined (P for trend = 0.0107) and women (P for trend = 0.0003), but not in men. Adjusted ORs of the lowest quartile group were significantly higher than the highest group in men and women combined (OR = 1.39, 95 % CI: 1.06-1.81) and women (OR = 1.89, 95 % CI: 1.31-2.72).Depressive symptoms were self-reported.Low vitamin D levels were associated with a high risk of depressive symptoms, especially in women. Women are thus considered a major target for preventing vitamin D deficiency to address depression.
Databáze: OpenAIRE
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