Randomised double-blind study comparing tropisetron alone and in combination with dexamethasone in the prevention of acute and delayed cisplatin-induced emesis
| Autor: | C. Vadell, A. Salvador, G. Pérez Manga, I. Bover, P. Viladiu, M.a.M. Barros, Victor Moreno, Xavier Garcia-del-Muro, X. Fabregat, M. Beltrán, J. Rifa, J.R. Germà |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research Indoles Vomiting medicine.drug_class Nausea Tropisetron Administration Oral Antineoplastic Agents Placebo Dexamethasone Double-Blind Method medicine Humans Antiemetic Infusions Intravenous Aged business.industry Middle Aged Drug Combinations Treatment Outcome Oncology Anesthesia Chemoprophylaxis Antiemetics Corticosteroid Female Cisplatin medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Cancer. 34:193-195 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(97)00367-5 |
| Popis: | In a randomised, double-blind and parallel-design multicentre study, 282 chemotherapy-naive cancer patients received tropisetron 5 mg intravenously (i.v.) before high-dose cisplatin on day 1, and oral tropisetron 5 mg daily on days 2–6, in combination with either placebo ( n =143) or dexamethasone ( n =135), given i.v. on day 1 and orally on days 2–6. Complete protection from acute vomiting/nausea was achieved in 76.3%/79.3% of patients receiving the combination and in 55.2%/61.5% of those receiving tropisetron alone. Complete protection on days 2–6 from delayed vomiting/nausea was obtained in 60%/60% and 39.2%/40.6%, respectively. Tropisetron in combination with dexamethasone is safe and more effective than tropisetron alone in the prevention of both acute and delayed cisplatin-induced emesis. |
| Databáze: | OpenAIRE |
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