Relative Ability of Mitogens to Stimulate Production of Interferon by Lymphoid Cells and to Induce Suppression of the in Vitro Immune Response

Autor:	Samuel Baron, G J Stanton, Howard M. Johnson
Rok vydání:	1977
Předmět:	T cell Cell Biology General Biochemistry Genetics and Molecular Biology In vitro medicine.anatomical_structure Immune system Antigen Interferon Cell culture Immunology medicine Inducer medicine.drug
Zdroj:	Experimental Biology and Medicine. 154:138-141
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-154-39622
Popis:	SummarySeveral T cell mitogens, con-canavalin A (Con A), phytohemagglutinin P (PHA-P), and staphylococcal enterotoxin A (SEA), were compared for their ability to inhibit the in vitro antibody response and to stimulate the production of mitogen (antigen) -type interferon in mouse spleen cell cultures. It was found that the ability to inhibit the plaque-forming cell (PFC) response to sheep red blood cells was proportional to the ability of these mitogens to induce interferon in the cultures. SEA was the most effective inhibitor of the PFC response and the best inducer of mitogen-type interferon, followed by Con A, with PHA-P being the least effective. The data suggest that SEA would be the most suitable inducer of mitogen-type interferon in quantity as a prerequisite to purification and characterization of the molecule. The data are supportive of previous studies suggesting a role for mitogen (antigen) -type interferon in regulation of the immune response via suppressor T cells.We wish to thank Ms. Phyllis ...
Databáze:	OpenAIRE
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