Epidemiology and Risk Factors for Coronary Artery Abnormalities in Children With Complete and Incomplete Kawasaki Disease During a 10-Year Period
| Autor: | Athanasios Michos, Chryssa Tzoumaka-Bakoula, Paraskevi Papadogeorgou, Ioannis Kopsidas, George P. Chrousos, Georgia Giannouli |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Heart disease Coronary Artery Disease Mucocutaneous Lymph Node Syndrome Lower risk Epidemiology Confidence Intervals Odds Ratio medicine Humans Immunologic Factors Retrospective Studies Greece business.industry Incidence Incidence (epidemiology) Immunoglobulins Intravenous Infant Retrospective cohort study Odds ratio Prognosis medicine.disease Child Preschool Pediatrics Perinatology and Child Health Female Kawasaki disease Cardiology and Cardiovascular Medicine business Follow-Up Studies Systemic vasculitis |
| Zdroj: | Pediatric Cardiology. 34:1476-1481 |
| ISSN: | 1432-1971 0172-0643 |
| Popis: | Kawasaki disease (KD) is an acute systemic vasculitis of childhood. The diagnosis is based on clinical criteria. However, the presentation of KD is incomplete/atypical for approximately 20 % of patients. Kawasaki disease is complicated with coronary artery lesions (CALs) and considered the most common cause of acquired heart disease in children. The medical records of children discharged with KD from a tertiary pediatric hospital in Athens, Greece, during a decade (2001-2010) were retrospectively analyzed. During the study period, KD was diagnosed for 86 children younger than 14 years of age. Complete diagnostic criteria were fulfilled by 64 of the children (74.4 %), whereas 25.6 % were considered incomplete cases. Cardiovascular complications were detected in 48 children (55.8 %) and CALs in 28 children (32.6 %). The prevalence of CALs did not differ significantly between complete and incomplete/atypical KD (42.2 vs 4.5 %; P = 0.001). Logistic regression analysis showed that erythema in the lips and oral cavity was associated with the development of CALs [odds ratio (OR), 3.03; 95 % confidence interval (CI), 1.051-8.783; P = 0.040]. Conversely, children with incomplete/atypical KD (OR, 0.092; 95 % CI, 0.010-0.816; P = 0.032) and previous antibiotic treatment (OR, 0.17; 95 % CI, 0.036-0.875; P = 0.034) were less likely to experience CALs. Children with an incomplete/atypical presentation of KD or before antibiotic treatment may be at lower risk for the development of CALs. Future multicenter studies may help to establish this association better. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink