Prevention of relapses in systemic lupus erythematosus
| Autor: | Pieter Limburg, J. Wolters-Dicke, P. Spronk, Jo Hermans, R. H. W. M. Derksen, C. G. M. Kallenberg, F H Gmelig-Meyling, G. de Boer, H. Bootsma, L. Kater |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Cyclophosphamide Gastroenterology immune system diseases Prednisone Internal medicine Azathioprine medicine Humans Lupus Erythematosus Systemic Prospective Studies skin and connective tissue diseases Prospective cohort study Aged Autoantibodies Lupus erythematosus Cumulative dose business.industry General Medicine DNA Middle Aged medicine.disease Connective tissue disease Endocrinology Treatment Outcome Prednisolone Female business medicine.drug Follow-Up Studies |
| Zdroj: | Lancet (London, England). 345(8965) |
| ISSN: | 0140-6736 |
| Popis: | Many relapses of systemic lupus erythematosus (SLE) are preceded by a rise in antibodies against double-stranded DNA (anti-dsDNA). We investigated whether these relapses can be prevented by giving prednisone when a rise in anti-dsDNA occurs. 156 patients with SLE were studied. Anti-dsDNA was measured by Farr assay monthly. When a rise in anti-dsDNA was found, patients were randomly assigned either conventional treatment or 30 mg prednisone added to the current daily dose and tapering off to baseline over 18 weeks. A rise in anti-dsDNA was detected in 46 patients (24 assigned conventional treatment and 22 prednisolone). The relapse rate was higher in the conventional group than in the prednisolone group (20 vs 2, p < 0.001). Although rises in anti-dsDNA in the prednisone group were treated with additional prednisone, the cumulative oral doses of prednisone in the two groups did not differ significantly (p = 0.025). 7 major relapses requiring additional cytotoxic immunosuppressive treatment occurred in the conventional group versus 2 in the prednisone group. Treatment with prednisone as soon as a significant rise in anti-dsDNA occurs prevents relapse in most cases, without increasing the cumulative dose of prednisdone given. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |