Genome wide association study of fatty acid composition in Duroc swine
| Autor: | Viterbo, Vanessa S., Lopez, Bryan Irvine M., Kang, Hyunsung, Kim, Hoonseop, Song, Choul-won, Seo, Kang Seok |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Candidate gene lcsh:Animal biochemistry Genome-wide association study Single-nucleotide polymorphism Biology Genome Article 03 medical and health sciences chemistry.chemical_compound Gene lcsh:QP501-801 lcsh:SF1-1100 chemistry.chemical_classification Genetics Fatty acid Stearoyl-CoA Desaturase (SCD) Gene Animal Breeding and Genetics Stearoyl-CoA Desaturase () Gene Genome Wide Association Study (GWAS) Duroc Oleic acid 030104 developmental biology chemistry Animal Science and Zoology Stearic acid lcsh:Animal culture Fatty Acid Food Science |
| Zdroj: | Asian-Australasian Journal of Animal Sciences, Vol 31, Iss 8, Pp 1127-1133 (2018) Asian-Australasian Journal of Animal Sciences |
| ISSN: | 1976-5517 1011-2367 |
| Popis: | Objective Genome wide association study was conducted to identify and validate candidate genes associated with fatty acid composition of pork. Methods A total of 480 purebreed Duroc pigs were genotyped using IlluminaPorcine60k bead chips while the association test was implemented following genome-wide rapid association using Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approach. Results A total of 25, 29, and 16 single nucleotide polymorphisms (SNPs) were significantly associated with stearic (18:0), oleic (18:1) and saturated fatty acids (SFA), respectively. Genome wide significant variants were located on the same region of swine chromosome 14 (SSC14) that spanned from 120 to 124 Mb. Top SNP ALGA008191 was located at 5 kb near the stearoyl-CoA desaturase (SCD) gene. This gene is directly involved in desaturation of stearic acid into oleic acid. General relationship of significant SNPs showed high linkage disequilibrium thus genome-wide signals was attributed to SCD gene. However, understanding the role of other genes like elongation of very long chain fatty acids-3 (ELOVL3) located on this chromosomal segment might help in further understanding of metabolism and biosynthesis of fatty acids. Conclusion Overall, this study provides evidence that validates SCD gene as strong candidate gene associated with fatty acid composition in Duroc pigs. Moreover, this study confirms significant SNPs near ELOVL3 gene. |
| Databáze: | OpenAIRE |
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