Lipid profile in women over 35 years old using triphasic combined oral contraceptives
| Autor: | Tânia Regina Leme Martinez, José Mendes Aldrighi, Geraldo Rodrigues de Lima, Luis Bahamondes, Carlos Alberto Petta, Maria Eugenia Caetano |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Apolipoprotein B Population Levonorgestrel Ethinyl Estradiol Drug Administration Schedule chemistry.chemical_compound Oral administration Ethinylestradiol Internal medicine medicine Humans Risk factor education Triglycerides education.field_of_study medicine.diagnostic_test biology business.industry Cholesterol Cholesterol HDL Obstetrics and Gynecology Cholesterol LDL Lipids Contraceptives Oral Combined Endocrinology Reproductive Medicine chemistry biology.protein Female lipids (amino acids peptides and proteins) Apoproteins business Lipid profile medicine.drug |
| Zdroj: | Contraception. 69:395-399 |
| ISSN: | 0010-7824 |
| Popis: | Twenty-nine women aged 35 years old or more, using triphasic combined oral contraceptive (COC) were evaluated during six cycles for the following parameters: total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and its subfraction HDL2, triglycerides, apoproteins A and B, Castelli risk index I and II (cholesterol/HDL-C and LDL-C/HDL-C) and apoprotein ratio (apoprotein B/apoprotein A). The same laboratory measurements were done in a control group of 49 non-COC-user women. The results showed that there were no differences on most of the studied parameters between user and nonuser women. There was a significant reduction of HDL-C and HDL2-C, although within the normal range. In addition, it was observed a significant increment of triglycerides and apoprotein B at 6 months of follow-up only in user group (p < 0.05), although within the normal range. It is concluded that the use of levonorgestrel triphasic COC appeared to have no additional adverse impact when used by women aged over 35 years. Further studies are needed to obtain conclusive data. |
| Databáze: | OpenAIRE |
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