Macular thinning in prediabetes or type 2 diabetes without diabetic retinopathy

Autor: Eline E B De Clerck, Nicolaas C. Schaper, Miranda T. Schram, Fleur Goezinne, Carroll A.B. Webers, Pieter C. Dagnelie, Jan S. A. G. Schouten, Coen D.A. Stehouwer, Tos T. J. M. Berendschot
Přispěvatelé: Medical Image Analysis, MUMC+: MA AIOS Oogheelkunde (9), RS: CARIM - R3 - Vascular biology, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Oogheelkunde (9), Oogheelkunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: MA Endocrinologie (9), Interne Geneeskunde, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: MA Oogheelkunde (3)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Blood Glucose
0301 basic medicine
Male
retina
genetic structures
Macula Lutea/pathology
Type 2 diabetes
SDG 3 – Goede gezondheid en welzijn
Cohort Studies
0302 clinical medicine
Macula Lutea
Prediabetes
Prospective Studies
Tomography
Netherlands
education.field_of_study
Multivariable linear regression
neurodegeneration
General Medicine
Diabetic retinopathy
Middle Aged
Type 2/complications
Female
type 2 diabetes
Tomography
Optical Coherence
Cohort study
medicine.medical_specialty
Glycated Hemoglobin A/metabolism
Population
Prediabetic State
Prediabetic State/complications
03 medical and health sciences
Retinal Diseases
SDG 3 - Good Health and Well-being
Internal medicine
Ophthalmology
Diabetes Mellitus
medicine
Journal Article
Humans
education
Glycated Hemoglobin
optical coherence tomography
Diabetic Retinopathy
Thinning
Blood Glucose/metabolism
business.industry
Diabetes Mellitus
Type 2/complications
medicine.disease
Confidence interval
eye diseases
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
Retinal Diseases/etiology
Optical Coherence
030221 ophthalmology & optometry
sense organs
business
Zdroj: Acta Ophthalmologica, 96(2), 174-182. Wiley-Blackwell
Acta Ophthalmologica, 96(2), 174-182. Wiley
ISSN: 1755-3768
1755-375X
Popis: PURPOSE: To assess macular thinning in individuals with prediabetes or type 2 diabetes without diabetic retinopathy (DM2 w/o DR) compared with individuals with normal glucose metabolism (NGM).METHODS: Using spectral domain optical coherence tomography (SD-OCT), we measured macular thickness in six subfields as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) in 1838 participants from The Maastricht Study, a population-based cohort study (mean age 59 ± 8 years, 49% men, 1087 NGM, 279 prediabetes, 472 DM2 w/o DR). Multivariable linear regression was used to assess the association between macular thickness and glucose metabolism status.RESULTS: After adjustment for age, sex and spherical equivalent, individuals with prediabetes showed a significant decrease in pericentral superior macular thickness [β = -2.14 μm (95% confidence interval (CI): -4.24 to -0.03), p < 0.05] compared with individuals with NGM. In individuals with DM2 w/o DR, the fovea [β = -4.05 μm (95% CI: -6.30 to -1.79), p < 0.001] and the four pericentral quadrants (range: β = -4.64 to -5.29 μm, p < 0.001) were significantly thinner compared with individuals with NGM. There was a significant linear trend of macular thinning with severity of glucose metabolism status in five subfields (p < 0.001).CONCLUSION: Macular thickness is reduced in prediabetes and a greater reduction occurs in DM2, even before DR is clinically present. About half of the thinning observed in DM2 w/o DR was already found in prediabetes. Generalized thinning of the macula could be related to thinning of the temporal side of the optic nerve head through the connecting papillo-macular bundle.
Databáze: OpenAIRE
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