The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer
| Autor: | Simone Chevalier, Eleonora Scarlata, Ana O'Flaherty, Nadia Ekindi-Ndongo, Fred Saad, Mathieu Latour, Bernard Têtu, Michel Carmel, Ginette McKercher, Saro Aprikian, Armen Aprikian, Fadi Brimo, Louis Lacombe, Claudie Laprise, Michel D. Wissing |
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| Rok vydání: | 2018 |
| Předmět: |
Nephrology
Oncology Biochemical recurrence Adult Male medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Logistic regression Body Mass Index Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Humans Obesity Prospective Studies Treatment Failure Prospective cohort study Exercise Aged Proportional Hazards Models Aged 80 and over Prostatectomy business.industry Margins of Excision Prostatic Neoplasms Middle Aged medicine.disease 3. Good health Logistic Models Treatment Outcome 030220 oncology & carcinogenesis Cohort Multivariate Analysis business Body mass index |
| Zdroj: | World journal of urology. 37(5) |
| ISSN: | 1433-8726 |
| Popis: | We evaluated whether an increased body-mass index (BMI) and decreased physical activity increase the risk of locally advanced or high-risk prostate cancer (PCa) at radical prostatectomy (RP), and treatment failure after surgery.Data were collected from the PROCURE Biobank, a prospective cohort of patients with localized PCa undergoing RP in four academic centers in Québec between 2006 and 2013. Treatment failure was defined as biochemical recurrence and/or initiation of secondary, non-adjuvant therapy, and analyzed using the Kaplan-Meier method, log-rank tests, and Cox proportional-hazards models. Uni- and multivariate (ordered) logistic regression was used for time-independent variables.1813 patients were included. Median follow-up time was 69 months. Patients who reported a lower BMI were generally older, of Asian descent, and physically more active (p 0.05). Younger, black, and overweight/obese patients reported less physical activity (p 0.05). In multivariate analyses, a higher BMI increased the risk for locally advanced, high-risk PCa (defined as a pT3, N1 and/or Gleason 8-10 tumor; odds ratio 1.33, p 0.001), but increased physical activity did not predict high-risk disease (odds ratio 0.84, p = 0.39). Patients with a higher BMI also had a larger prostate at surgery (odds ratio 1.13, p = 0.03). BMI and physical activity were not associated with positive surgical margins or time to treatment failure (p 0.05).BMI was an independent predictor for locally advanced, high-risk disease in this cohort of PCa patients undergoing RP, but was unrelated to treatment failure. Physical activity was not related to locally advanced, high-risk PCa or treatment failure. |
| Databáze: | OpenAIRE |
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